Paraphrenia has hippocampal pyramidal cells, tangles, some amyloid plaque - Brain Disease Histology

21 августа, 2003
Paraphrenia is characterized by preservation of hippocampal pyramidal cells, neurofibrillary tangles, and little amyloid plaque. Immunotherapy Weekly via NewsEdge Corporation : Paraphrenia is characterized by preservation of hippocampal pyramidal cells, neurofibrillary tangles, and little amyloid plaque. According to a study from the United States, "A recent article classifies paraphrenia within the tauopathy spectrum. More specifically, neurofibrillary changes appear restricted to the hippocampus and are accompanied by scant amyloid deposition. "The present study adds the preservation of hippocampal (CA1) pyramidal cell numbers to the neuropathological findings of paraphrenia," wrote M.F. Casanova and coauthors. The researchers concluded: "The lack of cell loss not only distinguishes paraphrenia from Alzheimer disease but offers, in addition, a marked similarity to a condition denoted in the medical literature as senile dementia with tangles." Casanova and colleagues published their study in Schizophrenia Research (Preservation of hippocampal pyramidal cells in paraphrenia. Schizophr Res, 2003;62(1-2):141-146). For more information, contact M.F. Casanova, Med College Georgia, Downtown VA Med Center 24, 26 Psychiatry Service, Room 3B-121, 1 Freedom Way, Augusta, GA 30910, USA. Publisher contact information for the journal Schizophrenia Research is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands. The information in this article comes under the major subject areas of Diagnostics, Histology, Proteomics and Neurology. This article was prepared by Immunotherapy Weekly editors from staff and other reports. <> << Copyright ©2003 NewsRx.com >>
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