RNA editing of serotonin 2C receptor may play role in depressive disorders - Mental Health

04 сентября, 2003
RNA editing of the serotonin 2C receptor may play a role in the development of depressive disorders. Pain & Central Nervous System Week via NewsEdge Corporation : RNA editing of the serotonin 2C receptor (HTR2C) may play a role in the development of depressive disorders. The importance of HTR2C "in mental disorders has been implicated by studies of HTR2C-deficient mice and linkage and association studies," scientists in Japan explained. "Recent studies have revealed that RNA editing of HTR2C is involved in mental disorders." K. Iwamoto and colleagues at the Institute of Physical and Chemical Research (RIKEN) "examined RNA editing efficiencies of site A and D of HTR2C in the prefrontal cortex samples of patients with bipolar disorder, schizophrenia, and major depression as well as control subjects by using primer extension combined with denaturing high performance liquid chromatography." "We could not find significant alterations of RNA editing efficiencies of these sites in patients," they reported. "However, we found trends for increased RNA editing efficiencies of site D in depressive patients (p=0.08) and site A in suicide victims (p=0.07)." "These findings are in accordance with the previous findings, and suggest that altered RNA editing of HTR2C may have some significance in major depression and suicide," they concluded. Iwamoto and coauthors published their study in Neuroscience Letters (RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neurosci Lett, 2003;346(3):169-172). For additional information, contact T. Kato, RIKEN, Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 3510198, Japan. The publisher's contact information for the journal Neuroscience Letters is: Elsevier Science Ireland Ltd., Customer Relations Manager, Bay 15, Shannon Industrial Estate, Co. Clare, Ireland. The information in this article comes under the major subject areas of Mental Health, Neuroscience and RNA Research. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. <> << Copyright ©2003 NewsRx.com >>
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