Atypical antipsychotics may be associated with developing glucose intolerance - New-Onset Diabetes

17 апреля, 2003
"Certain atypical antipsychotics may be associated with new-onset glucose intolerance, including acute diabetes and ketoacidosis," concludes a new study. Pain & Central Nervous System Week via NewsEdge Corporation : "Certain atypical antipsychotics may be associated with new-onset glucose intolerance, including acute diabetes and ketoacidosis," concludes a new study. Creighton University psychiatrists collected data from the Ohio Department of Mental Health database on patients treated with an atypical antipsychotic and treated or evaluated from diabetes. "Blood glucose levels, glucose tolerance, or other evaluations of diabetes had been conducted in 14 of the 126 patients treated with atypical antipsychotics," D.R. Wilson and colleagues found. They reported that "in 11 of the 14, new-onset, acute, and marked glucose intolerance developed after treatment with clozapine, olanzapine, or quetiapine. Of these, six patients required insulin therapy (four only transiently) and five patients developed diabetic ketoacidosis (DKA). "Also, glucose metabolism was labile in all cases, and was transient in two cases with subsequent resolution despite on-going antipsychotic therapy," the researchers said. They concluded, "Monitoring for changes in blood glucose levels in patients taking atypical antipsychotics may be indicated. More systematic study data are clearly needed." Wilson and colleagues published the results of their study in Schizophrenia Research (New-onset diabetes and ketoacidosis with atypical antipsychotics. Schizophr Res, 2003;59(1):1-6). The corresponding author for this report is D.R. Wilson, Creighton University, School of Medicine, Department Psychiatry, 3528 Dodge St., Omaha, NE 68131, USA. To subscribe to the journal Schizophrenia Research, contact the publisher: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands. The information in this article comes under the major subject areas of Adverse Drug Effects, Diabetes, Schizophrenia, New-Onset Glucose Intolerance, Ketoacidosis. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. <> << Copyright ©2003 NewsRx.com >>
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